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Results for "

p53 activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (2) Antibiotic (2) Apoptosis (28) Autophagy (6) Bcl-2 Family (3) Biochemical Assay Reagents (1) Casein Kinase (2) Caspase (4) Checkpoint Kinase (Chk) (1) Dihydroorotate Dehydrogenase (3) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (3) E1/E2/E3 Enzyme (5) Early 2 Factor (E2F) (1) Epigenetic Reader Domain (1) ERK (2) HDAC (2) HIF/HIF Prolyl-Hydroxylase (2) Histone Acetyltransferase (2) Isotope-Labeled Compounds (1) JNK (2) Lipoxygenase (1) MDM-2/p53 (45) Microtubule/Tubulin (3) Mitophagy (2) Mixed Lineage Kinase (1) NF-κB (1) Organoid (1) p38 MAPK (2) Parasite (5) PROTACs (1) Reactive Oxygen Species (4) RET (1) Sirtuin (6) STAT (2) TGF-β Receptor (1) Topoisomerase (1)
By Research Areas:	Cancer (65) Cardiovascular Disease (1) Endocrinology (1) Infection (6) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (2)

By Targets:

Adrenergic Receptor (1)

Akt (2)

Antibiotic (2)

Apoptosis (28)

Autophagy (6)

Bcl-2 Family (3)

Biochemical Assay Reagents (1)

Casein Kinase (2)

Caspase (4)

Checkpoint Kinase (Chk) (1)

Dihydroorotate Dehydrogenase (3)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (3)

E1/E2/E3 Enzyme (5)

Early 2 Factor (E2F) (1)

Epigenetic Reader Domain (1)

ERK (2)

HDAC (2)

HIF/HIF Prolyl-Hydroxylase (2)

Histone Acetyltransferase (2)

Isotope-Labeled Compounds (1)

JNK (2)

Lipoxygenase (1)

MDM-2/p53 (45)

Microtubule/Tubulin (3)

Mitophagy (2)

Mixed Lineage Kinase (1)

NF-κB (1)

Organoid (1)

p38 MAPK (2)

Parasite (5)

PROTACs (1)

Reactive Oxygen Species (4)

RET (1)

Sirtuin (6)

STAT (2)

TGF-β Receptor (1)

Topoisomerase (1)

By Research Areas:

Cancer (65)

Cardiovascular Disease (1)

Endocrinology (1)

Infection (6)

Inflammation/Immunology (3)

Metabolic Disease (2)

Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148404

p53 Activator 5	MDM-2/p53	Cancer
p53 Activator 5 (compound 134A) is a potent *p53* activator with a SC150 value of <0.05 mM. p53 Activator 5 can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA. p53 Activator 5 shows anti-tumor activity . p53 Activator 5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148402

p53 Activator 3	MDM-2/p53	Cancer
p53 Activator 3 (compound 87A) is a potent *p53* activator with a SC150 value of <0.05 mM. p53 Activator 3 can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA. p53 Activator 3 shows anti-tumor activity . p53 Activator 3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148416

p53 Activator 7	MDM-2/p53	Cancer
p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC₅₀ of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1) . p53 Activator 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-156919

p53 Activator 8	MDM-2/p53	Cancer
p53 Activator 8 (compound 5) is a p53 activator. p53 Activator 8 has potent anti-proliferative activity against MCF7 breast cancer cell lines with an IC ⁵⁰ value of 0.5 μM .

HY-160450

p53 Activator 11	MDM-2/p53	Cancer
p53 Activator 11 (compound A-1) is a potent *p53* activator with an EC₅₀ value of 0.478 µM for p53 (Y220C). p53 Activator 11 has the potential for the research of cancer .

HY-160449

p53 Activator 10	MDM-2/p53	Cancer
p53 Activator 10 (Example C-2) is a compound that targets the y220c mutant of *p53. p53* Activator 10 activation is involved in the downstream effects of tumor suppression .

HY-160448

p53 Activator 9

Others Cancer

p53 Activator 9 (example D-4) is a p53 activator with EC₅₀ of 1.699μM .

p53 Activator 9	Others	Cancer
p53 Activator 9 (example D-4) is a p53 activator with EC₅₀ of 1.699μM .

HY-146095

p53 Activator 2	MDM-2/p53 DNA/RNA Synthesis Apoptosis	Cancer
p53 Activator 2 (compound 10ah) intercalats into DNA and results in significant DNA double-strand break.p53 Activator 2 increases the expression of *p53, p-p53, CDK4, p21 to cause cell cycle arrest at G2/M phase.p53 Activator* 2 induce apoptosis and significantly down-regulates the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1.p53 Activator 2 has anti-proliferation activity against MGC-803 cells, with an IC₅₀ of 1.73 µM. p53 Activator 2 displays potent anticancer efficiency against MGC-803 xenograft tumors models .

HY-155974

MeOIstPyrd	MDM-2/p53	Cancer
MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates *p53, and increases the half-life of p53* and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction .

HY-N12233

Condurango glycoside A	Apoptosis MDM-2/p53 Reactive Oxygen Species	Cancer
Condurango glycoside A is an activator of *p53. Condurango glycoside A initiates ROS* generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells .

HY-151170

MDM2/4-p53-IN-2	MDM-2/p53 Apoptosis	Cancer
MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/ MDM4 inhibitor and *p53* activator with the IC₅₀ values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity .

HY-108636

RETRA	MDM-2/p53	Cancer
RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects .

HY-19339

Tenovin-3

MDM-2/p53 Cancer

Tenovin-3 is a p53 activator .

Tenovin-3	MDM-2/p53	Cancer
Tenovin-3 is a *p53* activator .

HY-U00441

DPBQ 1 Publications Verification	MDM-2/p53 Apoptosis	Cancer
DPBQ activates *p53* and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind DNA. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells .

HY-U00442

CTX1 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
CTX1 is a *p53* activator that overcomes HdmX-mediated p53 repression. CTX1 exhibits potent anti-cancer activity in a mouse acute myeloid leukemia (AML) model system .

HY-148408

SIRT2-IN-11	Sirtuin	Cancer
SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC₅₀ value of 18.5 μM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers .

HY-110088

SCH529074 1 Publications Verification	MDM-2/p53	Cancer
SCH529074 is a potent and orally active *p53* activator. SCH529074 binds specifically and conformation-dependently to p53 DBD ( DNA binding domain) with a K_i of 1-2 μM in a saturable manner. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. SCH529074 can be used for the study of non-small-cell lung carcinoma (NSCLC) .

HY-162247

MDM2-IN-26	MDM-2/p53	Cancer
MDM2-IN-26 (compound A3) is an MDM2 inhibitor that can activate the tumor suppressor function of *p53* by blocking the interaction between MDM2 and p53 (MDM2 is the main negative regulator of p53). MDM2-IN-26 can be used for cancer research .

HY-108638

NSC 146109 hydrochloride 1 Publications Verification	MDM-2/p53 Apoptosis	Cancer
NSC 146109 hydrochloride is a small-molecule *p53* activator that target MDMX and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes .

HY-19896

COTI-2 2 Publications Verification	MDM-2/p53 Apoptosis	Cancer
COTI-2, an anti-cancer agent with low toxicity, is an orally available third generation activator of p53 mutant forms. COTI-2 acts both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. COTI-2 induces apoptosis in multiple human tumor cell lines. COTI-2 exhibits antitumor activity in HNSCC through p53-dependent and -independent mechanisms. COTI-2 converts mutant p53 to wild-type conformation .

HY-162432

MDM2-IN-27	MDM-2/p53	Cancer
MDM2-IN-27 targets MDM2 protein (K_i = 0.4 nM). MDM2-IN-27 activates the anti-tumor activity of p53 and induces apoptosis by blocking the negative regulation of p53 by MDM2 .

HY-126849

3-Morpholinosydnonimine SIN-1; Linsidomine	MDM-2/p53	Cancer
3-Morpholinosydnonimine (SIN-1; Linsidomine) is a spontaneous ROS/RNS generator and a peroxynitrite donor. 3-Morpholinosydnonimine inhibits hypertrophic chondrocytes activity and induces necrosis. 3-Morpholinosydnonimine induces *p53*-dependent apoptosis, induces *p53* accumulation and activates MAPK phosphorylation .

HY-110315

Ischemin sodium	Apoptosis MDM-2/p53 Epigenetic Reader Domain	Cardiovascular Disease
Ischemin sodium is a CBP bromodomain inhibitor that inhibits *p53* interaction with CBP and transcriptional activity in cells. Ischemin sodium salt inhibits *p53*-induced p21 activation with an IC₅₀ value of 5 µM. Ischemin sodium salt also prevents apoptosis in ischemic cardiomyocytes. Ischemin sodium salt can be used in the study of cardiovascular diseases (such as myocardial ischemia) .

HY-120084

BTX161	Casein Kinase	Cancer
BTX161, a Thalidomide analog, is a potent CKIα degrader. BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2 .

HY-100354

C16-Ceramide

1 Publications Verification

C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding .

C16-Ceramide 1 Publications Verification
C16-Ceramide is a natural small molecule activating *p53* through the direct and selective binding .

HY-13423

Tenovin-1 3 Publications Verification	MDM-2/p53 Dihydroorotate Dehydrogenase Sirtuin Autophagy	Cancer
Tenovin-1, a *p53* activator, protects p53 from MDM2-mediated degradation. Tenovin-1 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also a dihydroorotate dehydrogenase (DHODH) inhibitor .

HY-13811

NSC697923 1 Publications Verification	E1/E2/E3 Enzyme Apoptosis	Cancer
NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity .

HY-125858

MI-1061 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme Apoptosis	Cancer
MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC₅₀=4.4 nM; K_i=0.16 nM). MI-1061 potently activates *p53* and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity .

HY-15869

Inauhzin

2 Publications Verification

INZ
Sirtuin MDM-2/p53 Cancer

Inauhzin is a dual SirT1/IMPDH2 inhibitor, and acts as an activator p53, used in the research of cancer.

Inauhzin 2 Publications Verification INZ	Sirtuin MDM-2/p53	Cancer
Inauhzin is a dual SirT1/IMPDH2 inhibitor, and acts as an activator *p53*, used in the research of cancer.

HY-125858A

MI-1061 TFA 1 Publications Verification	MDM-2/p53 E1/E2/E3 Enzyme Apoptosis	Cancer
MI-1061 TFA is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC₅₀=4.4 nM; K_i=0.16 nM). MI-1061 TFA potently activates *p53* and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity .

HY-N4225

Aaptamine	Adrenergic Receptor	Endocrinology Cancer
Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of α-adrenoceptor and activates the p21 promoter in a p53-independent manner .

HY-P1562

PUMA BH3

Bcl-2 Family Cancer

PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM.
HY-14714

NSC-207895

1 Publications Verification

XI-006
MDM-2/p53 Cancer

NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator .
HY-P1562A

PUMA BH3 TFA

Bcl-2 Family Cancer

PUMA BH3 TFA is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM .
HY-19634

YK-3-237

Sirtuin Cancer

YK-3-237, a SIRT1 activator, targets mutant p53. YK-3-237 inhibits the proliferation of triple-negative breast cancer cells .

PUMA BH3	Bcl-2 Family	Cancer
PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM.

NSC-207895 1 Publications Verification XI-006	MDM-2/p53	Cancer
NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and *p53* activator .

PUMA BH3 TFA	Bcl-2 Family	Cancer
PUMA BH3 TFA is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a K_d of 26 nM .

YK-3-237	Sirtuin	Cancer
YK-3-237, a SIRT1 activator, targets mutant p53. YK-3-237 inhibits the proliferation of triple-negative breast cancer cells .

HY-103640

Amifostine thiol dihydrochloride WR-1065 dihydrochloride	MDM-2/p53	Cancer
Amifostine thiol (WR-1065) dihydrochloride can protect normal tissues from the toxic effects of certain cancer agents and activate *p53* through a JNK-dependent signaling pathway.

HY-W016181

Phenylhydroquinone 2-Phenylhydroquinone	MDM-2/p53 ERK p38 MAPK	Inflammation/Immunology
Phenylhydroquinone (PHQ) is an orally active thymic atrophy inducer which can up-regulate apoptosis through activation of *p53*. PHQ can be used for research of thymic atrophy .

HY-13735B

Quinacrine hydrochloride hydrate Mepacrine hydrochloride hydrate; SN-390 hydrochloride hydrate	Parasite Apoptosis Autophagy Mitophagy	Infection Cancer
Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis .

HY-163083

JN122	MDM-2/p53 Apoptosis	Cancer
JN122, a spiroindoline-containing molecule, is a MDM2 inhibitor. JN122 Inhibits MDM2/p53 protein–protein interaction and exerts robust in vivo antitumor efficacy. JN122 has antiproliferative activity in HCT-116 cells and HEK-293 cells with IC₅₀ values of 39.6 nM and 4.28μM, respectively. JN122 can promote activation of p53 and its target genes, inhibited cell cycle progression, and induced cell apoptosis .

HY-N7526

Naphthazarin 1 Publications Verification DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone	Apoptosis	Neurological Disease Cancer
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects .

HY-18935A

CBL0137 hydrochloride 3 Publications Verification Curaxin-137 hydrochloride; CBL-C137 hydrochloride	MDM-2/p53 NF-κB	Cancer
CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate *p53* and inhibits NF-κB with EC₅₀s of 0.37 and 0.47 µM, respectively.

HY-16271

Kevetrin hydrochloride 4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride	MDM-2/p53 Apoptosis	Cancer
Kevetrin hydrochloride is a potent activator of *p53*, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells .

HY-13735A

Quinacrine dihydrochloride 4 Publications Verification Mepacrine dihydrochloride; SN-390 dihydrochloride	Parasite Apoptosis Autophagy Mitophagy	Infection Cancer
Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis .

HY-130437

p-nitro-Pifithrin-α	MDM-2/p53 TGF-β Receptor Caspase	Infection Metabolic Disease
p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent *p53* inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease .

HY-16271S

Kevetrin hydrochloride-13C2,15N3	Isotope-Labeled Compounds MDM-2/p53	Cancer
Kevetrin (hydrochloride)- ¹³C₂, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.

HY-125858B

(S,R,S)-MI-1061	Others	Others
(S,R,S)-MI-1061 is the isomer of MI-1061(HY-125858). (S,R,S)-MI-1061 can used to synthesize Antibody-Drug Conjugates (ADCs). MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC₅₀=4.4 nM; K_i=0.16 nM). MI-1061 potently activates *p53* and induces apoptosis in the SJSA-1 xenograft tumor tissue in mice. Anti-tumor activity .

HY-108433

CPT2 Carnitine palmitoyltransferase 2	Apoptosis MDM-2/p53	Metabolic Disease Cancer
CPT2 (Carnitine palmitoyltransferase 2), an enzyme that participates in fatty acid oxidation, also is a colorectal cancer (CRC) prognostic biomarker. CPT2 overexpression can activate *p-p53* to increase *p53* expression, thereby inhibiting tumor proliferation and promoting apoptosis. CPT2 deficiency results in the most common inherited disorder of long-chain fatty acid oxidation affecting skeletal muscle. Downregulation of CPT2 is also highly correlated with the progression of various cancers and has potential for cancer research .

HY-N2693

6,8-Diprenylorobol	Apoptosis Reactive Oxygen Species Caspase Akt ERK JNK p38 MAPK Bcl-2 Family	Cancer
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS .

HY-137864

Amifostine thiol 1 Publications Verification WR-1065	MDM-2/p53	Cancer
Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway .

HY-N2602

Sanggenol L	MDM-2/p53	Cancer
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of *p53* in p

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7526

Naphthazarin 1 Publications Verification DHNQ; 5,8-Dihydroxy-1,4-naphthoquinone	Quinones Structural Classification other families Source classification Phenols Polyphenols Plants Naphthalene Quinones	Apoptosis
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects .

HY-N12233

Condurango glycoside A	Apocynaceae Structural Classification Marsdenia cundurango Rchb.f. Polysaccharides Source classification Plants Saccharides	Apoptosis MDM-2/p53 Reactive Oxygen Species
Condurango glycoside A is an activator of *p53. Condurango glycoside A initiates ROS* generation and up-regulates p53 expression. Condurango glycoside A induces apoptosis and pre-mature senescence associated with DNA damage in HeLa cells .

HY-N4225

Aaptamine	Alkaloids Classification of Application Fields Animals Source classification Marine natural products Quinoline Alkaloids Sponge Disease Research Fields Endocrinology	Adrenergic Receptor
Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of α-adrenoceptor and activates the p21 promoter in a p53-independent manner .

HY-N2693

6,8-Diprenylorobol	Structural Classification Flavonoids Source classification Maclura tricuspidata Carriere Plants Moraceae Isoflavones	Apoptosis Reactive Oxygen Species Caspase Akt ERK JNK p38 MAPK Bcl-2 Family
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS .

HY-N2602

Sanggenol L	Flavonoids Classification of Application Fields Morus mongolica (Bur.) Schneid. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	MDM-2/p53
Sanggenol L induces caspase-dependent and caspase-independent apoptosis in melanoma skin cancer cells . Sanggenol L induces of apoptosis via suppression of PI3K/Akt/mTOR signaling and cell cycle arrest via activation of *p53* in p

HY-N0636

Eriocitrin 1 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Citrus limon (L.) Burm. F. Flavonones Source classification Rutaceae Phenols Polyphenols Plants Disease Research Fields Cancer	Apoptosis
Eriocitrin is a flavonoid isolated from lemons that is a powerful antioxidant. Eriocitrin inhibits the proliferation of liver cancer cells by arresting the cell cycle in the S phase by upregulating p53, cyclin A, cyclin D3 and CDK6. Eriocitrin triggers apoptosis by activating intrinsic signaling pathways involving mitochondria .

HY-122815

Fusicoccin Fusicoccin A	Microorganisms Classification of Application Fields Terpenoids Source classification Diterpenoids Disease Research Fields Cancer	Apoptosis
Fusicoccin (Fusicoccin A), a fungal pytotoxin, is a stabilizer of specific 14-3-3 protein-protein interactions. Fusicoccin sabilizes H ⁺-ATPase/14-3-3 cmplex in pants, maintaining the enzyme in activated state. Fusicoccin also stabilizes 14-3-3 protein interactions with binding partners containing a C-terminal 14-3-3 recognition motif (a mode 3 motif), such as ERα, GPIbα, TASK3, CTFR, and p53. Fusicoccin induces apoptosis in cancer cells and has anticancer activity .

Cat. No.	Product Name	Chemical Structure

HY-B0413S

Fenbendazole-d3

2 Publications Verification

Fenbendazole-d₃ is a deuterium labeled Fenbendazole. Fenbendazole-d₃ is a HIF-1α agonist and activates the HIF-1α-related GLUT1 pathway. Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53[1][2][3][4].

HY-16271S

Kevetrin hydrochloride-13C2,15N3
Kevetrin (hydrochloride)- ¹³C₂, ¹⁵N₃ is the ¹³C-labeled and ¹⁵N-labeled Kevetrin (hydrochloride). Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.

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